Α-helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity

HIGHLIGHTS

• who: Jaime Santos from the Universitat SpainUniversity of have published the paper: α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: By using a time-resolved single-particle fluorescence approach, the authors demonstrate that short, amphipathic, and cationic α-helical peptides do not interact with the functional monomeric αS, but they bind toxic oligomers and fibrils with nanomolar affinity, resulting in the substoichiometric inhibition of αS aggregation and abrogation of oligomer-induced damage in neuronal cell models. DPSMα3 constitutes a suitable negative control for further . . .
  

   

  

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