Α-secretase-derived fragment of cellular prion, n1, protects against monomeric and oligomeric amyloid β (aβ)-associated cell death*

HIGHLIGHTS

• who: Marie-Victoire Guillot-Sestier from the Mock-transfected and APP WT- or APP LDN-expressing CHO cells were obtained by stable transfection of pc, empty vector and hAPP WT or hAPP LDN cDNA subcloned in pc, vectorCells were maintained in DMEM containing, % FBS, sodium hypoxanthine-thymidine supplement, and , ␮M proline. cDNA encoding APP LDN was obtained by site-directed mutagenesis of APP WT cDNA as described below. Cells were stably transfected with , ␮g of cDNA constructs according to Lipofectamine protocols reported previously (26). Clones were selected with , ␮g/ml Zeocin (Invitrogen). Conditioned Media from CHO Cell . . .
  

   

  

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