HIGHLIGHTS
- who: from the Tumanskyi Valerii Oleksiiovych MD, DSc, Professor, Department of Pathological Anatomy and Forensic Medicine, Zaporizhzhia State Medical University, Ukraine Hepatic encephalopathy (HE) is a frequent complication of liver cirrhosis, manifesting as a neuropsychiatric syndrome ranging from cognitive deficits to comaHE pathophysiology is linked to elevated brain ammonia and neuroinflammation [1]. Astrocytes are central brain cells responsible for ammonia detoxification and during acute HE are characterized by severe swelling [1]. Aquaporin, (AQP4) is a central protein of astrocytes, predominant water channel in the brain, which undergo alteration in response to hyperammonemia [2]. Studies have evidenced that . . .
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