HIGHLIGHTS
- who: MCR- and colleagues from the School of Cellular and Molecular Medicine, University of Bristol, Bristol , TD, England, and bDepartment of Medical have published the paper: 1.12 A resolution crystal structure of the catalytic domain of the plasmid-mediated colistin resistance determinant MCR-2, in the Journal: (JOURNAL)
SUMMARY
The polymyxin colistin is a key ‘last-resort' antibiotic used to treat infections by multidrug-resistant Gram-negative pathogens (Biswas et_al, 2012; Karaiskos et_al, 2017). The positively charged cyclic peptide of colistin binds to the negatively charged lipid A headgroup, with the hydrophobic . . .
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