11c-pib and 124i-antibody pet provide differing estimates of brain amyloid-β after therapeutic intervention

HIGHLIGHTS

  • who: C-PiB et al. from the DepartmentUppsala University have published the paper: 11C-PiB and 124I-Antibody PET Provide Differing Estimates of Brain Amyloid-β After Therapeutic Intervention, in the Journal: (JOURNAL) of September/22,/2010
  • what: The aim of this study was to compare an antibody-based ligand targeting nonfibrillar Ab with after b-secretase (BACE-1) inhibition in 2 Alzheimer disease mouse models at an advanced stage of Ab pathology. This study demonstrated the ability of an antibody-based radioligand to detect changes in brain Ab levels after anti-Ab therapy in ArcS . . .

     

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