1,2,4-trioxolane and 1,2,4,5-tetraoxane endoperoxides against old-world leishmania parasites: in vitro activity and mode of action

HIGHLIGHTS

• who: Andreia Mendes et al. from the Instituto Higiene e Medicina Tropical (IHMT), Universidade Nova Lisboa (UNL), Rua da Junqueira have published the paper: 1,2,4-Trioxolane and 1,2,4,5-Tetraoxane Endoperoxides against Old-World Leishmania Parasites: In Vitro Activity and Mode of Action, in the Journal: Pharmaceuticals 2022, 446 of 14/Nov/2021
• what: Our findings showed that the selected endoperoxides LC132 and LC138 induce some biochemical and morphological alterations, causing oxidative stress.
• how: The results showed that L infantum and L donovani promastigotes are susceptible to all peroxides . . .
  

   

  

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