13-amino derivatives of dehydrocostus lactone display greatly enhanced selective toxicity against breast cancer cells and improved binding energies to protein kinases in silico

HIGHLIGHTS

• who: Douglas Kemboi and collaborators from the Department of, Tshwane University of Technology, Pretoria, South Africa, Department of have published the research: 13-amino derivatives of dehydrocostus lactone display greatly enhanced selective toxicity against breast cancer cells and improved binding energies to protein kinases in silico, in the Journal: PLOS ONE of 22/02/2022
• what: The experiment was done in technical triplicate and the data were analyzed using GraphPad Prism Inc, (USA) with half-maximal inhibitory concentration (IC50 values) determined by non-linear regression. In this study, the binding strength, binding poses, and protein . . .
  

   

  

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