13c pyruvate transport across the blood-brain barrier in preclinical hyperpolarised mri

HIGHLIGHTS

• who: Jack J. Miller from the (UNIVERSITY) have published the Article: 13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI, in the Journal: (JOURNAL) of 10/05/2018
• what: Through the use of_[1-13C]pyruvate and ethyl-[1-13C]pyruvate in naïve brain, a rodent model of metastasis to the brain, or porcine brain subjected to mannitol osmotic shock, the authors show that pyruvate transport across the blood-brain barrier of anaesthetised animals is rate-limiting.
• future: Issues relating to pyruvate transport and partial volume effects must therefore . . .
  

   

  

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