2-apqc, a small-molecule activator of sirtuin-3 (sirt3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis

HIGHLIGHTS

• What: The staining of HE organ tissue in the high-dose 2APQC treatment group and the normal body weight of these groups during the experiment showed no obvious toxicity (Fig 2w). The results of this study showed that p-p38MAPK levels were significantly increased in the ISO group but decreased after 2-APQC treatment, while the total p38 levels did not vary significantly between groups (Fig 6c). The authors show for the first time that PYCR1 is significantly inhibited in ISO-induced HF rat models, accompanied by a significant reduction in proline. The authors demonstrated that 2 . . .
  

   

  

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