2-arylpropionic acid pyrazolamides as cannabinoid cb2 receptor inverse agonists endowed with anti-inflammatory properties

HIGHLIGHTS

  • who: Daniela R. de Oliveira and colleagues from the Universidade Federal do Rio Janeiro, Rio Janeiro, RJ, Brazil have published the Article: 2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties, in the Journal: Pharmaceuticals 2022, 1519 of 30/04/2019
  • what: In this context this work describes a series of five novel designed molecular hybrids of dipyrone metabolites and NSAIDs such ibuprofen and flurbiprofen. This work describes new structural analogs of arachidonylpyrazolamides, and_(6), which exploit the replacement of the arachidonate subunit (A, Figure 2) for a substituted . . .

     

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