2-deoxyglucose transiently inhibits yeast ampk signaling and triggers glucose transporter endocytosis, potentiating the drug toxicity

HIGHLIGHTS

• who: Clotilde Laussel et al. from the Universitu00e9 Paris Citu00e9, CNRS, Institut Jacques Monod, Paris, FranceEditor: Martin CSchmidt, University of Pittsburgh have published the paper: 2-deoxyglucose transiently inhibits yeast AMPK signaling and triggers glucose transporter endocytosis, potentiating the drug toxicity, in the Journal: (JOURNAL) of March/28,/2022
• what: The authors focus on the contribution of a Snf1 substrate in 2DG resistance namely the alpha-arrestin Rod1 involved in nutrient transporter endocytosis. The authors report that 2DG triggers the endocytosis of many plasma membrane proteins mostly in a Rod1-dependent manner. The authors show . . .
  

   

  

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