2-styrylchromones prevent il-1-induced pro-inflammatory activation of fibroblast-like synoviocytes while increasing cox-2 expression “2279

HIGHLIGHTS

SUMMARY

Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive and chronic synovial inflammation, leading to irreversible cartilage and bone damage. The already explored anti-inflammatory activities of 2-SC showed potential for reactive pro-oxidant species scavenging, modulation of human neutrophils` oxidative burst, inhibition of NF-κB activation and production of cytokines/chemokine in THP-1 monocytes, inhibition of COX1 activity, and leukotriene B4 production in human polymorphonuclear leukocytes, as well as inhibition of lymphocyte function-associated molecule-1/intercellular cell adhesion molecule-1-mediated cell adhesion, in HL-60 cells. Cell-based . . .

 



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