HIGHLIGHTS
SUMMARY
A potent Fc-engineered human monoclonal antibody (mAb), named MAD0004J08, neutralizes in_vitro multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) variants of concern, such as alpha, beta, gamma, and delta, and the omicron variant, though with reduced potency. The authors compared the sensitivity of 2D 1 H-13 C ALSOFAST-HMQC NMR spectra with that of immunochemical ELISA-based analysis in assessing the HOS of MAD0004J08 mAb. SARS-CoV-2 mAbs batches 19G, 20G, and 33G were obtained from Menarini Biotech, Analytical Development, Latina, Italy. The distance values between the spectra of each . . .
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