3-deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in mice

HIGHLIGHTS

• who: Ana Guerrero from the University of have published the research work: 3-Deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in mice, in the Journal: (JOURNAL)
• what: This analysis showed a reversion of senescence signatures (Fig 7c and Extended Data Fig 10d).
• how: While expression of TRF2u0394Bu0394M causes telomere uncapping and results in a DNA damage response that mimics what the authors observed during senescence21 the authors decided to assess the effect that treatment with 3DA has on cells undergoing replicative senescence. The mice determined by the animal facility . . .
  

   

  

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