HIGHLIGHTS
- who: ChemBioChem and collaborators from the (UNIVERSITY) have published the article: 3,4,5‐Trihydroxypiperidine Based Multivalent Glucocerebrosidase (GCase) Enhancers, in the Journal: (JOURNAL)
- what: The authors report the synthesis of a series of new multivalent trihydroxypiperidines bearing a C9-linker at the nitrogen atom and their biological evaluation towards human GCase. The authors report the synthesis of new multivalent compounds (tri-, tetra- and hexavalent iminosugars) by CuAAC reaction of an azido ending trihydroxypiperidine with several propargylated scaffolds.
- how: This approach derives from the observation of the counter-intuitive effect of glycosidases inhibitors . . .
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