HIGHLIGHTS
- who: Huan Zhang and collaborators from the University of California, Davis, United States have published the article: 3D CRISPR screen in prostate cancer cells reveals PARP inhibitor sensitization through TBL1XR1-SMC3 interaction, in the Journal: (JOURNAL)
- what: The authors focused on TBL1XR1 for further study since this gene showed more significant effect on olaparib sensitivity in both 2D and 3D culture and has been implicated in tumorigenesis and resistance to chemotherapy treatment in several reports .
- how: For 3D culture the authors used Nunclonu2122 Spherau2122 Dishes (Thermo Scientific Cat. A list of all primary . . .
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