HIGHLIGHTS
- who: Konstantin Okonechnikov from the (UNIVERSITY) have published the paper: 3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma, in the Journal: (JOURNAL) of 28/Dec/2022
- what: The authors show that structural variants in supratentorial ependymomas not only lead to ZFTA-RELA fusion genes, but also result in the formation of new regulatory environments that are recurrently associated with aberrant overexpression of RCOR2. The authors show that PFA ependymoma is another tumor type with a global epigenetic phenotype in which there is hypermethylation of CTCF binding_sites and associated changes . . .
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