HIGHLIGHTS
SUMMARY
There is no universally accepted protocol and main focus of initial research projects was the in_vivo investigation of angiogenesis antiangiogenic drugs. The CAM model can be regarded as an in_vivo model that incorporates the 3R principle ("replace, reduce, refine") for the prevention of unnecessary suffering of animals due to research purposes. [58] Hypoxia-induced de novo transcription of uPAR mRNA in pancreatic cancer cell lines Tumor-induced angioinvasion of human pancreatic cancer cells in_vitro and in_vivo may depend on hypoxia Depletion of PKD2 in the endothelium in sprouting assays and tumor xenografts inhibited tumor . . .
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