HIGHLIGHTS
SUMMARY
The crystal_structures of myoglobin by John Kendrew (Kendrew et_al, 1958; Kendrew et_al, 1960) and hemoglobin by Max Perutz (Perutz, 1960; Perutz, 1962) largely confirmed Pauling`s hypotheses. To direct measurement of log Po/w, considerable effort has been expended in developing prediction algorithms, with hundreds of articles and dozens of reviews or benchmarking studies (Buchwald and Bodor, 1998; Grassi et_al, 2002; Machatha and Yalkowsky, 2005; Aliagas et_al, 2022). Most reported X-ray crystallographic and cryoelectron microscopic structures of membrane_proteins do not contain native-like lipids due to a plethora of issues in extracting and . . .
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