4-phenylbutyric acid (4-pba) derivatives prevent sod1 amyloid aggregation in vitro with no effect on disease progression in sod1-als mice

HIGHLIGHTS

• who: Leenor Alfahel et al. from the Department of Physiology and Cell Biology and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, POBox, Beer Sheva, Braunschweig, Germany have published the research: 4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice, in the Journal: (JOURNAL)
• what: The authors investigated the potential therapeutic effect of C4 and C5 two of the chemical chaperone By combining in vivo and in vitro techniques the authors show that although C4 and C5 successfully inhibited . . .
  

   

  

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