5`-chalcogen-substituted nucleoside pyrophosphate and phosphate monoester analogues: preparation and hydrolysis studies

HIGHLIGHTS

• who: Satu Mikkola and collaborators from the Department of Chemistry, University of Turku, Turku, Finland have published the article: 5`-Chalcogen-Substituted Nucleoside Pyrophosphate and Phosphate Monoester Analogues: Preparation and Hydrolysis Studies, in the Journal: (JOURNAL)
• what: The authors show that pyrophosphorothiolate pyrophosphoroselonolate-linked dinucleosides. unprecedentedthese pyrophosphorothiolate or pyrophosphoroselonolate-linked dinucleohave considerably higher chemical resilience towards acid pH than the corresponding sides. The results obtained in this study show that the effect of substitution of sulfur for a phosphate oxygen depends significantly on the structure of a biological phosphate compound, and consequently, on the reaction . . .
  

   

  

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