5-formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity

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• who: Kazuhiro Yamada from the Kazuhiro Yamada1, *, Johnny Mendoza1, and Markos Koutmos1, , * From the Department of Chemistry, Program in Biophysics, and Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, USA Edited by Wolfgang Peti have published the article: 5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity, in the Journal: (JOURNAL) of December/24,/2022
• what: The authors focus on the novel folate-binding mode of CHO-H4folate in the active_site of tMTHFR. Although repositioning the Glu side chain against the isoalloxazine ring of FAD may relate . . .
  

   

  

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