6α-hydroxylated bile acids mediate tgr5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice

HIGHLIGHTS

• who: Kassem Makki and collaborators from the The Wallenberg Laboratory, University of Denmark have published the research: 6u03b1-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice, in the Journal: Gut microbiota of 11/Nov/2021
• what: The authors show that oligofructose sustains the production of 6u03b1-hydroxylated bile acids from primary bile acids by gut bacteria when fed western-u00adstyle diet. The authors show that the 6u03b1-hydroxylated bile acid hyodeoxycholic acid stimulates TGR5 signalling, in_vitro and in_vivo, and increases GLP-u00ad 1R activity to improve host . . .
  

   

  

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