[68ga]ga-dota-siglec-9 detects pharmacodynamic changes of fap-targeted il2 variant immunotherapy in b16-fap melanoma mice

HIGHLIGHTS

• who: Riikka Viitanen and collaborators from the University, China have published the paper: [68Ga]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice, in the Journal: (JOURNAL)
• what: The authors focused on longitudinal quantitative PET/CT imaging with VAP-1-targeting Ga-DOTA-Siglec-9 to assess the pharmacodynamic effect of the novel tumortargeting FAP-IL2v immunocytokine in mice bearing B16-FAP melanoma tumors.

SUMMARY

There is prominent evidence that VAP-1 is involved in the accumulation of CD8+ T_cells and natural . . .

 



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