89zr-onartuzumab pet imaging of c-met receptor dynamics

HIGHLIGHTS

  • who: Martin Pool from the Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands have published the research: 89Zr-Onartuzumab PET imaging of c-MET receptor dynamics, in the Journal: (JOURNAL)
  • what: HCC827 tumours in this study showed high contrast and c-MET-specific 89Zr-onartuzumab uptake at a tracer protein dose of 10 μg.
  • how: For ease of clinical translation the authors selected the therapeutic antibody-based PET tracer 89 Zr-onartuzumab which has been reported to effectively discriminate cMET expression in human gastric cancer xenografts .
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