HIGHLIGHTS
- who: Top from the CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France Department of Pathology, University of Melbourne, Parkville, Australia have published the paper: Pregnane X-receptor promotes stem_cell-mediated colon cancer relapse, in the Journal: (JOURNAL)
- what: The authors show that the nuclear receptor Pregnane X Receptor (PXR NR1I2) behaves as a key driver of CSC-mediated tumor recurrence. The authors demonstrate that PXR expression and activity are indeed highly restricted to CSCs, where it drives the expression of a large network of genes that are instrumental for CSC chemoresistance in_vitro and in_vivo . . .
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