Temozolomide analog pmx 465 downregulates mgmt expression in hct116 colorectal carcinoma cells

HIGHLIGHTS

• who: PMX et al. from the Medical School, Kunming University of Science and Technology, Kunming, China have published the article: Temozolomide Analog PMX 465 Downregulates MGMT Expression in HCT116 Colorectal Carcinoma Cells, in the Journal: (JOURNAL)

SUMMARY

Typical p53-binding_sites in the MGMT promoter, several studies have found that the tumor suppressor p53 impacts MGMT expression(Bobustuc et_al, 2015; Bocangel et_al, 2009; Natsume et_al, 2005). It has been reported that p53 protein directly interacts with the MGMT promoter and downregulates MGMT transcription(Natsume et_al, 2005). The TMZ derivative C8-methyl imidazole tetrazine, 3 . . .

 



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