Cocl2-mimicked endothelial cell hypoxia induces nucleotide depletion and functional impairment that is reversed by nucleotide precursors

HIGHLIGHTS

  • who: Barbara Kutryb-Zajac et al. from the Department of Biochemistry, Medical University of Gdansk, Debinki , St, Gdansk, Poland have published the research work: CoCl2-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors, in the Journal: Biomedicines 2022, 1540 of /2022/
  • what: This work demonstrated for the first time that combined application of the precursors 4.for The authors showed that CoCl2 -stimulated ECs revealed decreased eNOS phosphorylation (Ser1177) and phospho-eNOS/total-eNOS ratio, which rather suggested that 24 h CoCl2 treatment displayed similar effects on . . .

     

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