Genomic, transcriptomic, and metabolomic profiles of hipsc-derived dopamine neurons from clinically discordant brothers with identical prkn deletions

HIGHLIGHTS

• who: Holly N. Cukier from the Derivation, validation and differentiation of hiPSCs hiPSC lines were derived from dermal fibroblasts from two human subjects, PM and SM, who underwent a dermal biopsy at age , and, respectively, after providing the appropriate patient consent/assent under the guidelines of an approved Internal Review Board (IRB) protocol at Vanderbilt University (#080369)Four independent hiPSC clones from each patient were used in this study (PM1, PM12, PM17, and SM3, SM5, and SM15). Three of the hiPSC lines (PM1, SM3, SM5) were generated by transducing the fibroblasts with a lentivirus as previously described38 . . .
  

   

  

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