HIGHLIGHTS
- who: Claire E. Coupland from the Division University of Oxford, Roosevelt Drive, Oxford , BN, UK have published the research work: Structure, mechanism, and inhibition of Hedgehog acyltransferase, in the Journal: (JOURNAL) of December/16,/2021
- what: The authors propose a model of HHAT function based on the structures . The authors provide a structural template for the development of HHAT inhibitors, a validated alternative strategy to inhibit SHH signaling.
- how: The data are also supported by the recently determined cryo-EM structure of HHAT bound to its product palm-SHH peptide (Jiang et_al 2021 . . .
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