Alzheimer’s disease-like app processing in wild-type mice identifies synaptic defects as initial steps of disease progression

HIGHLIGHTS

• who: Mickael Audrain from the France France France France have published the Article: Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression, in the Journal: (JOURNAL)
• what: The authors aimed at deciphering the modifications occurring in vivo during the very early stages of AD before the development of amyloid deposits neurofibrillary tangles neuronal death and inflammation. The authors aimed at recapitulating in_vivo key features that are suspected to account for triggering AD, more specifically an increased Aβ42/Aβ40 ratio, while avoiding major APP . . .
  

   

  

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