Point mutations in fimh adhesin of crohn’s disease- associated adherent-invasive escherichia coli enhance intestinal inflammatory response

HIGHLIGHTS

• who: Intestinal Inflammatory Response and collaborators from the M2iSH, Université d'Auvergne, USC-INRA, Clermont-Ferrand, France, Institute of Hygiene, University Hospital Münster, Münster, Germany have published the research: Point Mutations in FimH Adhesin of Crohn’s Disease- Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response, in the Journal: (JOURNAL) of January/24,/2013
• what: The authors demonstrate that not only mobile genetic modules but also point mutations facilitate the rapid adaptation of E. coli, particularly AIEC strains, to changing environmental conditions and hence extend the spectrum of infection sites.
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