Hexokinase ii detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels

HIGHLIGHTS

• who: Federica Chiara and collaborators from the CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Padova, Italy, Department of Biological Chemistry and Venetian Institute have published the paper: Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels, in the Journal: (JOURNAL) of March/19,/2008
• what: The authors show that a hexokinase II N-terminal peptide selectively detaches hexokinase II from mitochondria and activates apoptosis. The authors show that cell death mediated by HK detachment from mitochondria is selectively sensitive to modulators . . .
  

   

  

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