HIGHLIGHTS
- who: Antoine Campagne from the Research University France, INSERM, Mines ParisTech, Paris, France. have published the paper: BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- how: Primer sequences for qPCR analysis are provided in Supplementary Table 1.
SUMMARY
To comprehend the role of BAP1 in transcriptional regulation, the authors generated knockouts (KOs) for BAP1, ASXL1, ASXL2, and EZH2, the main catalytic subunit of PRC2, in human HAP1 cells, a model cell line that is nearly haploid and thus particularly amenable to genome . . .
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