Amyotrophic lateral sclerosis (als) and adenosine receptors

HIGHLIGHTS

• who: Ana M. Sebastião from the Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal, Instituto United States have published the paper: Amyotrophic Lateral Sclerosis (ALS) and Adenosine Receptors, in the Journal: (JOURNAL)

SUMMARY

Mutations in C9ORF72 are also frequently found in fALS and accounts for 10% of the sporadic cases (DeJesus-Hernandez et_al, 2011; Smith et_al, 2013). Motor neurons with C9ORF72 mutations have increased expression and activity of NMDA receptors and calcium permeable AMPA receptors (Selvaraj et_al, 2018; Shi et_al, 2018), known to be targets for . . .

 



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