HIGHLIGHTS
- who: Jun-ichiro Takahashi from the DepartmentUniversity of have published the paper: Synchronous intracellular delivery of EGFR-targeted antibody-drug conjugates by p38-mediated non-canonical endocytosis, in the Journal: Scientific Reports Scientific Reports
- what: The authors focused on the clinically available agents, cisplatin and temozolomide because they are known to trigger the continuous non-canonical endocytosis of E GFR27,31,37. In the present study, endocytic sorting was applied to ADC therapy, and the results obtained demonstrated that TNF-α induced the synchronous intracellular delivery of the cetuximab/panitumumab-EGFR complex via p38-dependent CME . . .
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