HIGHLIGHTS
- who: Aldo Hernandez-Corchado from the Department of Human Genetics, McGill University, Montreal, QC H A , Canada have published the research: Toward a base-resolution panorama of the in vivo impact of cytosine methylation on transcription factor binding, in the Journal: (JOURNAL)
- what: The authors show that JAMS models quantitatively explain TF occupancy recapitulate cell type-specific TF binding and have high positive predictive value for identification of TFs affected by intra-motif methylation. While this study provides in_vitro evidence for widespread recognition of methylated CpGs by TFs, a comparable systematic analysis of in_vivo methylation . . .
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