HIGHLIGHTS
- What: This model proposes neighboring PBB3 molecules forming T-shaped π-π stacking through their benzothiazole rings, which stabilize PBB3 along the pocket, geometry echoed in the APN-1607-Tau fibril structure (Fig 1j).
- Who: Qinyue Zhao from the (UNIVERSITY) have published the research work: A Tau PET tracer PBB3 binds to TMEM106B amyloid fibril in brain, in the Journal: (JOURNAL)
SUMMARY
This revelation prompts critical question regarding whether existing PET tracers, initially designed for Tau and Aβ, might also recognize TMEM106B fibril. To meticulously quantify the extra densities at both binding_sites, the . . .
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