Tasl mediates keratinocyte differentiation by regulating intracellular calcium levels and lysosomal function

HIGHLIGHTS

• Who: Ji Yeong Park from the SchoolNational University have published the research: TASL mediates keratinocyte differentiation by regulating intracellular calcium levels and lysosomal function, in the Journal: Scientific Reports Scientific Reports

SUMMARY

TASL deficiency inhibits the proliferation and migration of HaCaT_cells by inducing G1/S arrest HaCaT_cells are immortalized human keratinocytes widely used for studying epidermal homeostasis. To investigate the effects of TASL deficiency on certain characteristics that influence epidermal homeostasis in keratinocytes, such as proliferation, migration, and differentiation, the authors established TASL KO HaCaT_cells using a lentiCRISPR v2 vector. TASL deficiency affects . . .

 



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