Evaluating the role of neddylation modifications in kidney renal clear cell carcinoma: an integrated approach using bioinformatics, mln4924 dosing experiments, and rna sequencing

HIGHLIGHTS

• What: The authors observed that Cluster 3, characterized by the high expression of several proto-oncogenes including catenin beta 1 (CTNNB1), BRAF, KRAS, and PIK3CA, appears to be a critical determinant of poor prognosis in patients with KIRC . In the study focusing on KIRC, a comprehensive analysis of DNA methyltransferase 1 (DNMT1) and HDACs was conducted. To interpret the biological significance of these expression changes, the authors conducted a Disease Ontology (DO) analysis, focusing on the gene function-disease correlation. Meanwhile, the research has elucidated that PSMB10, a gene fundamentally involved in the ubiquitin-proteasome system, is . . .
  

   

  

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