Cct6a facilitates lung adenocarcinoma progression and glycolysis via stat1/hk2 axis

HIGHLIGHTS

• What: CCT6A enhanced the protein stability of STAT1 via suppressing ubiquitination Given established role of the CCT family in protein binding and stabilization, the authors aimed to explore whether CCT6A could enhance HK2 expression through this mechanism. The authors aimed to elucidate the impact of CCT proteins on the progression of LUAD. Subsequently, the authors focused on the downstream molecules of CCT6A that facilitate aerobic glycolysis. The authors demonstrate that CCT6A could bind to and stabilize the STAT1 protein, reducing its ubiquitination, and then promoted LUAD cell glycolysis, proliferation, and migration through the transcriptional upregulation of HK2 . . .
  

   

  

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