Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool

HIGHLIGHTS

• What: Collectively, the study demonstrates that Jag1/2 are important for maintaining esophageal and forestomach homeostasis and the onset of foregut SCC. The authors focused on studying the role of Jag1/2 in the maintenance of the esophageal epithelium. The authors aimed to investigate whether these changes occur in the Jag1/2 KO mutants. The authors demonstrate that Jag1/2 KO exacerbates inflammation and epithelial hyperplasia in the forestomach when exposed to bile acids.
• Who: Haidi Huang from the Mice p CreERT2/+, Jag1loxp/loxp and Jag2loxp/loxp mouse lines have been previously described67- Mice were . . .
  

   

  

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