Novel acetamide-based ho-1 inhibitor counteracts glioblastoma progression by interfering with the hypoxic–angiogenic pathway

HIGHLIGHTS

• What: This work aimed to investigate the link between HO-1 expression and the microenvironment of GBM by culturing two human glioblastoma cell lines (U87MG and A172) in the presence of a mimetic agent deferoxamine (DFX). Although HO-1 has been well-established in Although the therelationship relationshipamong amongROS, ROS,HIF1α, HIF1α,and and HO-1 has been well-established different cellular types , the impact of HO-1 and the hypoxic microenvironment in different cellular types , the impact of HO-1 and the hypoxic microenvironhas not yetnot been in GBM. in the present work, the authors aimed . . .
  

   

  

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