Generation of rhesus macaque embryos with expanded cag trinucleotide repeats in the huntingtin gene

HIGHLIGHTS

• What: Expanded CAG repeats also indirectly affect essential cellular processes for the following reasons . The authors employed the CRISPR/Cas9 system to assess the efficiency of directly targeting the expansion of the HTT CAG repeat in rhesus macaque zygotes. Nevprevious study, transgenic NHPs were developed as models for HD through the utilization ertheless, this study had a limitation in that the integration of the CAG repeat region was of the overexpression of exon 1 with extended CAG repeats of the human HTT gene introduced by a lentivirus.
• Who: Junghyun Ryu and collaborators from the Division . . .
  

   

  

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