Vitamin d regulates covid-19 associated severity by suppressing the nlrp3 inflammasome pathway

HIGHLIGHTS

• What: The authors used log-transformed normalized intensities in Linear Models for MicroArray data (LIMMA) analyses to identify differentially expressed genes between the diseased and control groups. The authors have demonstrated that one of the possible anti-viral mechanisms of VitD3 against SARS-CoV-2 infection could be attributed to the reduction in the activation of host NLRP3 inflammasome pathway. Aside from confounders related to demographic and clinical differences in patients of different cohorts, the main reason behind these contradictory findings could be attributed to the dose, timing, and form of VitD3 administered (i.e Calcifediol, cholecalciferol . . .
  

   

  

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