Detection and characterization of pancreatic and biliary tract cancers using cell-free dna fragmentomics

HIGHLIGHTS

• What: The aim of this study is to characterize the cfDNA fragmentomics in biliopancreatic cancers and develop an accurate method for detection. To view a copy of this __NEWPAGE__Shi 43:145 Conclusions the model demonstrated ultrasensitivity of plasma cfDNA fragementomics in detecting biliopancreatic cancers fulfilling the unmet accuracy of widely-used serum biomarker CA19-9 and provided an affordable way for accurate noninvasive biliopancreatic screening in clinical practice. Taken together, these results suggested that the model showed good performance for biliopancreatic detection even when using extremely low-coverage WGS data (0.5 ×). The authors focused on the . . .
  

   

  

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