The deletion of aqp4 and trpv4 affects astrocyte swelling/volume recovery in response to ischemia-mimicking pathologies

HIGHLIGHTS

• What: The authors examined astrocytic swelling/volume recovery in mice with TRPV4 and/or AQP4 deletion in response to in_vitro ischemic conditions, to determine how the deletion of these channels can affect the development of cerebral edema. In this study, when the volumetric changes of astrocytes were compared together, regardless of the existence of HRA and LRA groups, the authors observed no differences between Ctrl and Trpv4-/- mice which corresponds with the previous study, where the authors also did not see any differences between the volume responses of Trpv4-/- and Ctrl astrocytes in situ (Pivonkova et_al, 2018 . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.