Heat stress induces calcium dyshomeostasis to subsequent cognitive impairment through ers-mediated apoptosis via serca/perk/eif2α pathway

HIGHLIGHTS

• What: Model, the authors assessed learning and memory ability by conducting the MWM. The authors initially identified its differential expression through transcriptional screening and subsequently investigated its response to heat stress in both in_vivo and in_vitro settings using multiple techniques including RT-PCR, western blot, and immunofluorescence. This study proposes a crucial pathological function of SERCA in facilitating HS-induced activation of apoptosis and cognitive impairment. The authors initially observed no significant change in SERCA expression when compared to the HS group, suggesting that PERK may function downstream of SERCA and that heat exposure might first induce . . .
  

   

  

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