Xinbao pill ameliorates heart failure via regulating the sglt1/ampk/pparα axis to improve myocardial fatty acid energy metabolism

HIGHLIGHTS

• What: This study reveals a novel mechanism of XBW in HF through modulation of cardiac energy metabolism. SGLT1 overexpression blocked the effectiveness of XBW in treating myocardial pathologic changes and improving cardiac fatty_acid energy metabolism Furthermore, the authors investigate the impact of XBW against HF under overexpression of SGLT1 in NRCMs. The research showcased that XBW effectively triggers the activation of AMPK by enhancing the phosphorylation level of AMPK both in_vitro and in_vivo. The authors investigated the effects of XBW on FA metabolism in ISO-induced HF both in_vivo and in_vitro, elucidating its potential to ameliorate HF . . .
  

   

  

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