Insufficient pd-1 expression during active autoimmune responses: a deep single-cell proteomics analysis in inflammatory arthritis

HIGHLIGHTS

• What: 3.1 PD-1 is heterogeneously expressed across all leukocyte subsets in peripheral blood and synovial fluid A deep single-cell analysis was conducted to assess the presence and quantification of circulating PD-1+ leukocytes in biologic treatment-naive patients with inflammatory arthritis, utilizing mass cytometry. In contrast, the authors show for the first time that for PsA, increased frequencies of cells expressing PD-1 were noted mainly in cells of innate immunity as well as in those bridging innate and adaptive immunity, corroborating the hypothesis that these cells are important in the pathogenesis of this . . .
  

   

  

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